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Finally, in an independent study, 327 patients were randomized to open treatment with aripiprazole, haloperidol, olanzapine, quetiapine, risperidone, or ziprasidone for a minimum of 3 weeks.

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Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them.

The is exploring whether the incorporation of biologic measures into prediction algorithms can provide more accurate identification of young people who are at greatest risk for developing a psychotic disorder.

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Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia: A critical review and meta-analysis.

The partial D2- and 5-HT 1A-receptor agonist aripiprazole exerts differential agonistic and antagonistic effects in both the dopaminergic and the serotonergic systems and has been of beneficial impact on psychotic positive and negative symptoms as well as metabolic parameters when combined with clozapine (Barbui et al.

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One clinical study in agitated elderly patients compared the effects of tiapride, haloperidol and and found that while the two drugs had comparable efficacy superior to the placebo effect, tiapride had fewer and less severe side effects than haloperidol.

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These antipsychotics, with clozapine as the prototype, are distinguishable from their first-generation counterparts by a lower liability for extrapyramidal symptoms (EPS) and claims of improved efficacy that extend to other domains beyond psychosis (e.

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In conclusion, rechallenge with clozapine remains a viable option for patients with previous red alert who have not responded to trials with other antipsychotic medications but the patients have to be very carefully selected, weighing the risks and benefits.

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The impact upon extra-pyramidal side effects, clinical symptoms and quality of life of a switch from conventional to atypical antipsychotics (risperidone or olanzapine) in elderly patients with schizophrenia.

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